Idiopathic thrombocytopenic purpura (ITP) is defined as a hematologic disorder, characterized by isolated thrombocytopenia without a clinically apparent cause. 19 Jan Read our article and learn more on MedlinePlus: Immune thrombocytopenic purpura (ITP). 23 Feb Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease Purwanto I. Purpura trombositopenia idiopatik.

Author: Zulkizahn Kigazilkree
Country: Switzerland
Language: English (Spanish)
Genre: Art
Published (Last): 19 February 2017
Pages: 228
PDF File Size: 14.24 Mb
ePub File Size: 15.63 Mb
ISBN: 577-9-76384-765-4
Downloads: 49151
Price: Free* [*Free Regsitration Required]
Uploader: Nejin

On neurologic examination, any asymmetrical finding of recent onset. Southern Med J ; The size and appearance of the platelets idio;atik be abnormal. Short-term and long-term failure of laparoscopic splenectomy in adult immune diiopatik purpura udiopatik Background Idiopathic thrombocytopenic purpura ITPalso known as primary immune thrombocytopenic purpura and autoimmune thrombocytopenic purpura, is defined as isolated thrombocytopenia with normal bone marrow and in the absence of other causes of thrombocytopenia.

Therapy trombowitopenia adults with refractory chronic immune thrombocytopenic purpura.

Immune thrombocytopenic purpura might be an early hematologic manifestation of undiagnosed human immunodeficiency virus infection. Congenital and acquired thrombocytopenia.

No significant difference was noted in the rate of survival between males and females. Cost and mortality associated with hospitalizations in patients with immune thrombocytopenic purpura.

On fundoscopic examination, blurring of the optic trombosutopenia margins or retinal hemorrhage. In adults, it is more often a long-term chronic disease and can occur after a viral infection, with use of certain drugs, during pregnancy, or as part of an immune disorder. Foreign Atopic eczema Allergic urticaria Purpra rhinitis Hay fever Allergic asthma Anaphylaxis Food allergy common allergies include: Apr 23, Author: Nilsson T, Norberg B.


Keywords Idiopathic thrombocytopenic purpura; antiplatelet; antibodies; splenectomy; thrombopoietin. What would you like to print?


Identifying drugs that cause acute thrombocytopenia: Platelets help your blood clot by clumping together to plug small holes in damaged blood vessels.

Therefore, the former designation of reticuloendothelial system is considered imprecise. Serious infections in adults following splenectomy for trauma.

American College of Emergency Physicians Disclosure: In this, they differ from the previously discussed agents that act by attempting to curtail platelet destruction. However, in both children and adults, the cause of thrombocytopenia destruction of antibody-coated platelets by mononuclear macrophages appears to be similar. In adults, the peak prevalence is from years of age. An analysis for anti-platelet antibodies is a matter of clinician’s preference, as there is disagreement on whether the 80 percent specificity of purpurq test is sufficient to be clinically useful.

Immune thrombocytopenic purpura – Wikipedia

Factors predicting long-term responses to splenectomy in patients with idiopathic thrombocytopenic purpura. Trombositopeniw which have been bound by antibodies are taken up by macrophages in the spleen which have Fc receptorsand so removal of the spleen reduces platelet destruction. In adults older than 60 years, biopsy is used to exclude myelodysplastic syndrome or leukemia.

Bleeding time from minor lacerations or abrasions is usually prolonged. Autoantibody-coated platelets induce Fc receptor-mediated phagocytosis by mononuclear macrophages, primarily but not exclusively in the spleen.

The value of bone marrow evaluation for a diagnosis of ITP is unresolved [ 4 ]. Unresponsiveness to standard treatment after 6 months is an indication for bone marrow aspiration.


Pathogenesis of immune thrombocytopenia. Pseudothrombocytopenia due to platelet clumping is also a diagnostic consideration. The age-adjusted prevalence of ITP in Maryland was reported as 9. It is a thrombopoiesis stimulating Fc-peptide fusion protein peptibody. Epidemiology United States The annual incidence of immune thrombocytopenic purpura ITP is estimated to be five cases perchildren and two cases peradults, [ 2 ] but these data are not from large population-based studies. After several weeks of prednisone therapy, the dose is gradually reduced.

Past medical history revealed that patient was known case of epilepsy since 7 years of age and was on tablet eptoin, tablet carbamazepine for past 12 years. See Treatment and Medication for more detail. This website also contains material copyrighted by 3rd parties.

ITP is diagnosed by a low platelet count in a idjopatik blood count a common blood test. Purpura trombositopenia idiopatik R, Durette C. Intravenous Rh immune globulin for treating immune thrombocytopenic purpura. User Username Password Remember me. Older age and previous history of hemorrhage increase the risk of severe bleeding in adult ITP.

In adults whose treatment includes corticosteroids, a baseline pretreatment biopsy may prove useful for future reference, as corticosteroids can change marrow morphology.